The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.
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Burstein, S., Biotransformations of the Cannabinoids, in: Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs. Eds G. Barnett and C.N. Chiang. Biomed Publ., Forest City, California 1985.
Burstein, S., Hunter, S.A., Ozman, K., and Renzulli, L.,In vitro models of cannabinoid-induced psychoactivity, in: ‘Marihuana '84’. Ed. D.J. Harvey, IRL Press, Oxford 1985.
Burstein, S., Hunter, S.A., Ozman, K., and Renzulli, L., Biochem. Pharmac.33 (1984) 2653.
Burstein, S., Hunter, S. A., and Renzulli, L., J. Pharmac. exp. Ther.235 (1985) 87.
Burstein, S., Hunter, S.A., Latham, V., Mechoulam, R., Melchior, D.L., Renzulli, L. and Tefft, R.E. Jr, Life Sci.39 (1986) 1813.
Burstein, S., Hunter, S.A., Latham, V., and Renzulli, L., Biochem. Pharmac.35 (1986) 2553.
Pertwee, R.G., Br. J. Pharmac.46 (1972) 753.
Ohlsson, A., Widman, M., Carlsson, S., Ryman, T., and Strid, C., Acta pharmac. toxic.47 (1980) 308.
Fairbairn, J.W., and Pickens, J.T., Br. J. Pharmac.67 (1979) 379.
Perez-Reyes, M., Pharmacodynamics of Certain Drugs of Abuse, see ref. 2 in: Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs. Eds G. Barnett and C.N. Chiang, Biomed Publ., Forest City, California 1985.
Wall, M.E., and Brine, D.R., in: Marihuana: Biological Effects, pp. 36–38. Eds G.G. Nahas and W.D.M. Paton. Pergamon, Oxford 1979.
Hollister, L.E., et al., J. clin. Pharmac.21 (1981)171S; Cocchetto, D.M., Owens, S.M., Perez-Reyes, M., DiGuiseppi, S. and Miller, L.L., Psychopharmacology75 (1981) 158.
Sophia, R.D., Nalepa, S.D., Harakal, J.J., and Vassar, H.B., J. Pharmc. exp. Ther.186 (1973) 646.
We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report.
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Burstein, S., Hunter, S.A., Latham, V. et al. A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice. Experientia 43, 402–403 (1987). https://doi.org/10.1007/BF01940427