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Experientia

, Volume 43, Issue 4, pp 375–378 | Cite as

Human gene therapy: possibilities and limitations

  • Hj. Müller
Reviews

Summary

Gene therapy provides new options for medicine, and implies new responsibilities for making decisions relating to the limitations which reason and morality impose upon manipulation of the human genome for the benefit both of patients and of society. This contribution outlines the possibilities and limits of gene therapy in man from a medico-technical viewpoint.

Key words

Human gene therapy medical and ethical issues hereditary diseases gene transfer systems in vitro fertilization embryo transfer 

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References

  1. 1.
    Anderson, W. F., Prospects of human gene therapy. Science226 (1984) 401–409.PubMedGoogle Scholar
  2. 2.
    Baudet, A. I., Bibliography of cloned human DNA's. Am. J. hum. Genet.37 (1985) 386–406.PubMedGoogle Scholar
  3. 3.
    Bilheimer, D. W., Goldstein, J. L., Grundy, S. C., Starzl, T. E., and Brown, M. S., Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N. Engl. J. Med.311 (1984) 1658–1664.PubMedGoogle Scholar
  4. 4.
    Cline, M. J., Stang, H., Mercola, K., Morse, L., Ruprecht, R., Browne, J., and Salser, W., Gene transfer in intact animals. Nature284 (1980) 422–425.CrossRefPubMedGoogle Scholar
  5. 5.
    Constantini, F., and Jaenisch, R., (Eds) Genetic manipulation of the early mammalian embryo. Banbury report No. 20, Cold Spring Harbor Laboratory 1985.Google Scholar
  6. 6.
    Dick, J. E., Magli, M. C., Phillips, R. A., and Bernstein, A., Genetic manipulation of hematopoietic stem cells. Trends in Genetics2 (1986) 165–170.CrossRefGoogle Scholar
  7. 7.
    Donnall, Th. E., Marrow transplantation for nonmalignant disorders. N. Engl. J. Med.312 (1985) 46–47.PubMedGoogle Scholar
  8. 8.
    Krivit, W., Piermont, M. E., Ayaz, K., Tsai, M., Ramsay, N. K. C., Kersey, J. H., Weisdorf, S., Sibley, R., Snover, D., McGovern, M. M., Schwartz, M. F., and Desnick, R. J., Bone marrow transplantation in the Maroteaux-Lamy-syndrome (Mucopolysaccharidosis Type VI). N. Engl. J. Med.311 (1984) 1606–1611.PubMedGoogle Scholar
  9. 9.
    Müller, Hj., Human in vitro fertilization and embryo transfer: expectations and concerns. Experientia41 (1985) 1515–1517.PubMedGoogle Scholar
  10. 10.
    Müller, Hj., Gentherapie beim Menschen, eine Standortanalyse. Veröffentlichung des Schweiz. Institutes für Rechtsvergleich, Vol. 4. Lausanne 1986.Google Scholar
  11. 11.
    Mulligan, R. C., and Berg, P., Experession of a bacterial gene in mammalian cells. Science209 (1980) 1422–1427.PubMedGoogle Scholar
  12. 12.
    Neumann, E., Schaefer-Ridder, M., Wang, Y., and Hofschneider, P. H., Gene transfer into mouse L-cells by electroporation in high electric fields. EMBO J.1 (1982) 841–845.PubMedGoogle Scholar
  13. 13.
    Palmiter, R. D., and Brinster, R. L., Transgenic mice. Cell41 (1985) 343–345.CrossRefPubMedGoogle Scholar
  14. 14.
    Parkman, R., The application of bone marrow transplantation to the treatment of genetic diseases. Science232 (1986) 1374–1378.Google Scholar
  15. 15.
    Pellicer, A., Wigler, M., Axel, R., and Silverstein, S., The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell14 (1979) 133–141.CrossRefGoogle Scholar
  16. 16.
    Proceedings of the III. World Congress of in vitro Fertilization and Embryo Transfer, Helsinki, Finland (1984).Google Scholar
  17. 17.
    Schaffner, W., Direct transfer of cloned genes from bacteria to mammalian cells. Proc. natn. Acad. Sci. USA (1980) 2163–2167.Google Scholar
  18. 18.
    Shapiro, L. J., Treatment of genetic diseases, in: Principles and Practice of Medical Genetics, pp. 1488–1496. Eds A. E. H. Emery and D. Rimoin. Churchill Livingstone, Edinburgh and London 1983.Google Scholar
  19. 19.
    Spradling, A. C., and Rubin, G. M., The effecxt of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene. Cell34 (1983) 47–57.CrossRefPubMedGoogle Scholar
  20. 20.
    Williams, D. A., Orkin, S. H., and Mulligan, R. C., Retrovirus-mediated transfer of human adenosine deaminase sequences into cells in culture into murine hematopoietic cell vivo. Proc. natn. Acad. Sci. USA83 (1986) 2566–2570.Google Scholar

Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • Hj. Müller
    • 1
    • 2
  1. 1.Dept. of Human GeneticsUniversity Children's HospitalBasel
  2. 2.Laboratory of Human GeneticsDept. of Research of the University Clinics, KantonsspitalBasel(Switzerland)

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