, Volume 46, Issue 7, pp 680–682 | Cite as

Exogenous fibronectin modifies the aggregation of collagen-stimulated human platelets

  • A. R. Eynard
  • M. E. Pasqualini
  • R. A. Rovasio
Research Articles


Fibronectins (FN) are adhesive glycoproteins whose role in platelet aggregation is unclear. Addition of 3, 6 and 12 μg/ml of human plasma FN in vitro to isolated human platelets, which had been freed from plasma FN by gel filtration and subsequently stimulated with collagen, inhibited the last stage of platelet aggregation. With 3 and 6μg/ml of FN a shortening of the lag-time was also observed. These data showed that FN may play a role in platelet-collagen interaction as well as in platelet-platelet interaction.

Key words

Platelet aggregation fibronectin 


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Copyright information

© Birkhäuser Verlag Basel 1990

Authors and Affiliations

  • A. R. Eynard
    • 1
  • M. E. Pasqualini
    • 1
  • R. A. Rovasio
    • 2
  1. 1.II Catedra de Histologia (FCM)Ciudad UniversitariaCordoba(Argentina)
  2. 2.Catedra de Histologia y Embriologia Animal (FCEFN), Instituto de Biologia Celular (UNC-CONICET), Agencia de Correos No. 4Ciudad UniversitariaCordoba(Argentina)

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