, Volume 46, Issue 7, pp 672–676 | Cite as

Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans

  • M. Martinelli
  • R. Winterhalder
  • P. Cerretelli
  • H. Howald
  • H. Hoppeler
Research Articles


Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+235%) and satellite cells (+215%) were observed.

Key words

Muscle morphometry human hypoxia lipofuscin satellite cell high altitude 


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Copyright information

© Birkhäuser Verlag Basel 1990

Authors and Affiliations

  • M. Martinelli
    • 1
  • R. Winterhalder
    • 1
  • P. Cerretelli
    • 2
  • H. Howald
    • 3
  • H. Hoppeler
    • 1
  1. 1.Department of AnatomyUniversity of BernBern 9
  2. 2.Department of PhysiologyUniversity of Geneva, CMUGenève 4
  3. 3.Ciba-Geigy AGBasel(Switzerland)

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