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Intact teratogenic immunoglobulins may reach the rat embryo

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It is known that heterologous antiserum against rat kidney homogenate may induce congenital malformations when injected into pregnant rats during the period of organogenesis. Teratogenic rabbit antibodies against a purified rat renal tubular glycoprotein were isolated, labelled with125I and injected into pregnant rats on the 10th day of gestation. Extracts of visceral yolk-sacs (VYS) and embryos were obtained 16 h later and chromatographed separately on a Sephacryl S-300 gel filtration column. The resultant chromatograms showed several radioactive peaks, one of which coincided with the eluate of intact rabbit immunoglobulins G (IgG). We interpret the result as an indication that some undigested intact teratogenic IgG were present in VYS and the embryo.

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Authors and Affiliations

  1. Department of Anatomy, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 07103, Newark, New Jersey, USA

    Ch. C. K. Leung & B. Cheewatrakoolpong

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  1. Ch. C. K. Leung
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  2. B. Cheewatrakoolpong
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Leung, C.C.K., Cheewatrakoolpong, B. Intact teratogenic immunoglobulins may reach the rat embryo. Experientia 44, 1017–1018 (1988). https://doi.org/10.1007/BF01939908

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  • DOI: https://doi.org/10.1007/BF01939908

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