Summary
Doxorubicin (DXR) (0.17×10−4) induces an acute cardiotoxicity in isolated rat heart; there is a progressive widening of the SαT segment, with a decrease in force derivatives and in the coronary flow. Concurrent perfusion with fructose-1,6-diphosphate (FDP) (10−5–10−4) dose-dependently reduces the SαT enlargement but fails to affect the reduction in force derivatives and coronary flow. The target of cardiac protection by FDP might be the ionic mechanisms underlying the action potential configuration.
References
Young, R. C., Ozols, R. F., and Myers, C. E., N. Engl. J. Med.305 (1981) 139.
Doroshow, J. H., Cancer Res.43 (1983) 460.
Myers, C. E., McGuire, W. P., Liss, R. H., Ifrim, I., Grotzinger, K., and Young, R. C., Science197 (1977) 165.
Neri, B., Cini-Neri, G., and D'Alterio, M., Biochem. biophys. Res. Commun.125 (1984) 954.
Klugmann, F. B., Decorti, G., Candussio, L., Grill, V., Grill, V., Mallardi, F., and Baldini, L., Br. J. Cancer54 (1986) 743.
Markow, A. K., Oglethorpe, N. C., Blake, M. L., Lehan, P. H., and Hellems, H. K., Am. Heart J.100 (1980) 639.
Markow, A. K., Oglethorpe, N., Young, B. Y., and Hellems, K. H., Circ. Shock8 (1981) 9.
Danesi, R., Del Tacca, M., and Soldani, G., J. pharmac. Meth.16 (1986) 251.
Curtis, M. J., Macleod, B. A., Tabrizchi, R., and Walker, M. J. A., J. pharmac. Meth.15 (1985) 87.
Okano, C.., Kwok, O., Hokama, Y., and Chou, S. C., Res. Commun. Chem. Path. Pharmac.45 (1984) 279.
Saman, S., Jacobs, P., and Opie, L. H., Cancer Res.44 (1984) 1316.
Monti, E., Piccinini, F., Favalli, L., and Villani, F., Biochem. Pharmac.32 (1983) 3303.
Jensen, R. A., Acton, E. M., and Peters, J. H., J. Cardiovasc. Pharmac.6 (1984) 186.
Bermnardini, C., Del Tacca, M., Danesi, R., and Della Torre, P., Archs int. Pharmacodyn.283 (1986) 243.
Caroni, P., Villani, F., and Carafoli, F., FEBS Lett.130 (1981) 184.
Goto, M., Yatani, A., and Tsuda, Y., Jap. J. Physiol.27 (1977) 81.
Galzigna, L., and Rigobello, M. P., Experientia42 (1986) 138.
Doroshow, J. H., Locker, G. Y., and Myers, C. E., Cancer Treat. Rep.63 (1979) 855.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bernardini, N., Danesi, R., Bernardini, M.C. et al. Fructose-1,6-diphosphate reduces acute ECG changes due to doxorubicin in isolated rat heart. Experientia 44, 1000–1002 (1988). https://doi.org/10.1007/BF01939901
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01939901