Experientia

, Volume 46, Issue 6, pp 611–616 | Cite as

Glycolipid transfer protein and intracellular traffic of glucosylceramide

  • T. Sasaki
Article

Summary

Glycolipid transfer protein (GL-TP), a nonglycosylated protein with a molecular weight of 22,000 K, has been purified from pig brain. The protein transfers, by a carrier mechanism, glycolipids with a β-glucosyl or β-galactosyl residue directly linked to either ceramide or diacylglycerol. GL-TP appears to be present in most animal cells, and evidence has been obtained which indicates that it is a cytoplasmic protein. Little is known about the function of GL-TP. Current evidence indicates that glycosphingolipid glycosylation occurs at the luminal side of the Golgi apparatus, except for the glucosylation of ceramide, which has been shown to occur at the cytoplasmic side of the Golgi or endoplasmic membrane. It appears most likely that GL-TP participates in the intracellular traffic of glucosylceramide.

Key words

Glycosphingolipid topography of glycolipid glycosylation the Golgi apparatus glucosylceramide monensin glycolipid transfer protein 

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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • T. Sasaki
    • 1
  1. 1.Department of Biochemistry, Cancer Research InstituteSapporo Medical CollegeSapporo(Japan)

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