Experientia

, Volume 34, Issue 7, pp 879–881 | Cite as

Electronmicroscopic identification of type C particles in cultured murine neuroblastoma

  • S. Kataoka
  • T. H. Williams
  • D. Sandquist
  • S. K. Sahu
Specialia

Summary

Monolayer of murine neuroblastoma were treated with dexamethasone and examined by electronmicroscopy. Most of the treated cells were morphologically differentiated and exhibited type C virus particles which were budding from the cell surface. This in vitro system may be of great value for exploring the oncogenic potential of the virus, and its possible role in cell differentiation.

Keywords

Electronmicroscopy Cell Surface Dexamethasone Cell Differentiation Neuroblastoma 

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Literatur

  1. 2.
    W. Bernhard, in: Ultrastructure of Animal Viruses and Bacteriophages: an Atlas, p. 283. Ed. A.J. Dalton and F. Haguenau. Academic Press, New York 1973.Google Scholar
  2. 3.
    The Molecular Biology of Tumor Viruses, p. 502 Ed. J. Tooze. Cold Spring Harbor Laboratory, Cold Spring Harbor 1973.Google Scholar
  3. 4.
    D. Liebermann and L. Sachs, Nature, Lond.269, 173 (1977).Google Scholar
  4. 5.
    D.D. Myers, H. Meier, R.J. Huebner, L. Vernon and J. Walker, Nature, Lond.,234, 100 (1971).Google Scholar
  5. 6.
    A.M. Wu, L.S. Richardson, M. Paran and R.C. Gallo, Cancer Res.36, 2025 (1976).PubMedGoogle Scholar
  6. 7.
    K.N. Prasad and A.W. Hsie, Nature, Lond., New Biol.233, 141 (1971).Google Scholar
  7. 8.
    A.P. Anzil, D. Stavrou, K. Blinzinger, H. Herrlinger and E. Dahme, Cancer Res.37, 2236 (1977).PubMedGoogle Scholar
  8. 9.
    G. Augusti-Tocco and G.H. Sato, in: Control Mechanisms in the Expression of Cellular Phenotypes, p. 109. Ed. H.A. Padykula. Academic Press, New York 1970.Google Scholar
  9. 10.
    J. Ross, J.B. Olmsted and J.L. Rosenbaum, Tissue Cell7, 107 (1975).PubMedGoogle Scholar
  10. 11.
    K.N. Prasad, J. Zambernard, R. Lasher and M.H. VanWoert, Nature, Lond.228, 997 (1970).Google Scholar
  11. 12.
    D.I. Graham and N.K. Gontas, Neuropath. appl. Neurobiol.2, 451 (1976).Google Scholar
  12. 13.
    M. Hayano, J.H. Sung, C.W. Song and J.J. Clement, J. Neuropath. exp. Neurol.36, 62 (1977).PubMedGoogle Scholar
  13. 14.
    N.A. Wivel and G.H. Smith, Int. J. Cancer7, 167 (1971).PubMedGoogle Scholar
  14. 15.
    H. Herrlinger, A.P. Anzil, D. Stavrou, R. Heumann, B. Hamprecht and K. Blinzinger, J. Nat. Cancer Inst.55, 1473 (1975).PubMedGoogle Scholar
  15. 16.
    D. Sandquist, T.H. Williams, S.K. Sahu and S. Kataoka, Exp. Cell Res. (in press).Google Scholar
  16. 17.
    D. Sandquist, S.K. Sahu and T.H. Williams, Anat. Rec.187, 704 (1977).Google Scholar
  17. 18.
    K.N. Prasad, S.K. Sahu and S. Kumar, in: Differentiation and Control of Malignancy of Tumor Cells, p. 287. Ed. W. Nakahara, T. Ono, T. Sugimura and H. Sugano. University of Tokyo Press, Tokyo 1974.Google Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • S. Kataoka
    • 1
  • T. H. Williams
    • 1
  • D. Sandquist
    • 1
  • S. K. Sahu
    • 1
  1. 1.Department of Anatomy, College of MedicineUniversity of IowaIowa CityUSA

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