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Influence of treatment duration on audiogenic seizure susceptibility during barbiturate withdrawal in rats

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Summary

Barbiturate withdrawal seizure susceptibility in rats increased with increasing duration of treatment during a 15-day treatment period in which the animals were given an i.p. dose of sodium barbital every 12 h. This method of producing dependence has clear advantages over previously described methods.

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Literatur

  1. J. Crossland and B.E. Leonard, Biochem. Pharmac.12, suppl., 103 (1963).

    Google Scholar 

  2. J. Crossland and M. J. Turnbull, Neuropharmacology11, 733 (1972).

    PubMed  Google Scholar 

  3. C.F. Essig, Int. J. Neuropharmac.5, 103 (1965).

    Google Scholar 

  4. W.M. Bourn and R.G. Buice, Res. Commun. Psychol. Psychiat. Behav.1, 653 (1976).

    Google Scholar 

  5. J.H. Jaffe and S.K. Sharpless, J. Pharmac. exp. Ther.150, 140 (1965).

    Google Scholar 

  6. P.C. Jobe, A.L. Picchioni and L. Chin, J. Pharmac. exp. Ther.184, 1 (1973).

    Google Scholar 

  7. M.J. Turnbull and J.W. Watkins, Eur. J. Pharmac.36, 15 (1976).

    Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy, Northeast Louisiana University, 71209, Monroe, Louisiana, USA

    D. H. McGee & W. M. Bourn

Authors
  1. D. H. McGee
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  2. W. M. Bourn
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McGee, D.H., Bourn, W.M. Influence of treatment duration on audiogenic seizure susceptibility during barbiturate withdrawal in rats. Experientia 34, 873–874 (1978). https://doi.org/10.1007/BF01939675

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  • DOI: https://doi.org/10.1007/BF01939675

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