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Free radical intermediates produced by autoxidation of 1,8-dihydroxy-9-anthrone (dithranol) in pyridine

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Summary

The autoxidation of the antipsoriatic agent dithranol, monitored by an ESR-spectrometer, proceeds through several free radical intermediates. The initial radical, attacking a bulky spin trapping agent in a sterically comparatively hindered constellation, may be the active therapeutic form of dithranol.

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Authors and Affiliations

  1. Department of Wood and Polymer Chemistry, University of Helsinki, Snellmaninkatu 14, 00170, Helsinki 17, (Finland)

    J. Martinmaa, Leena Vanhala & K. K. Mustakallio

  2. Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, 00170, Helsinki 17, (Finland)

    J. Martinmaa, Leena Vanhala & K. K. Mustakallio

Authors
  1. J. Martinmaa
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  2. Leena Vanhala
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  3. K. K. Mustakallio
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Martinmaa, J., Vanhala, L. & Mustakallio, K.K. Free radical intermediates produced by autoxidation of 1,8-dihydroxy-9-anthrone (dithranol) in pyridine. Experientia 34, 872–873 (1978). https://doi.org/10.1007/BF01939674

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  • DOI: https://doi.org/10.1007/BF01939674

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