Summary
Ethanol pretreatment has the potentiation of the aflatoxin B1-induced hepatotoxicity was indicated by an increase in the activities of plasma GPT, plasma GOT and in the severity of liver necrosis. The effect of ethanol pretreatment on an increase in the accumulation of liver triglycerides is additive in nature.
Similar content being viewed by others
Literatur
L.E. Goldblatt, in: Aflatoxin. Scientific Background, Control and Implications. Academic Press, New York 1969.
R.C. Shank, N. Bhamarapravati, J.E. Gordon and G.N. Wogan, Fd Cosmet. Toxic.10, 171 (1972).
R.C. Shank, G.N. Wogan and J.B. Gibson, Fd Cosmet. Toxic.10, 51 (1972).
T. Glinsukon, W. Thamavit and M. Ruchirawat, J. Sci. Soc. Thailand2, 176 (1976).
M.J. Fletcher, Clin. chim. Acta.22, 393 (1968).
S. Reitman and S. Frankel, Am. J. clin. Path.28, 56 (1957).
M. Victor and R.D. Adams, Proc. Ass. Res. nerv. ment. Dis.32, 526 (1973).
T. Ariyoshi, E. Takabatake and H. Remmer, Life Sci.9, 361 (1970).
J.M. Khanna, H. Kalant, Y. Yee, S. Chung and A.J. Siemens, Biochem. Pharmac.25, 329 (1976).
D.H. Swenson, J.A. Miller and E.C. Miller, Biochem. biophys. Res. Commun.53, 1260 (1973).
D.H. Swenson, J.A. Miller and E.C. Miller, Proc. Am. Ass. Cancer Res., p. 43 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Glinsukon, T., Taycharpipranai, S. & Toskulkao, C. Aflatoxin B1 hepatotoxicity in rats pretreated with ethanol. Experientia 34, 869–870 (1978). https://doi.org/10.1007/BF01939671
Issue Date:
DOI: https://doi.org/10.1007/BF01939671