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Papaverine enhances the negative inotropic effect of acetylcholine in rat auricles

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Summary

The negative inotropic effect of acetylcholine in rat left auricles is enhanced in the presence of the phosphodiesterase inhibitor papaverine. This result favours the idea of a cyclic GMP-mediated action of acetylcholine in the heart.

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Authors and Affiliations

  1. Department of Pharmacology, University of Mainz, Obere Zahlbacher Str. 67, D-6500, Mainz, (Federal Republic of Germany)

    H. Nawrath

Authors
  1. H. Nawrath
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Additional information

I thank Lydia Paragnik for help. This research was supported by a grant from the Deutsche Forschungsgemeinschaft.

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Nawrath, H. Papaverine enhances the negative inotropic effect of acetylcholine in rat auricles. Experientia 34, 859–860 (1978). https://doi.org/10.1007/BF01939666

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  • DOI: https://doi.org/10.1007/BF01939666

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