Experientia

, Volume 34, Issue 7, pp 823–824 | Cite as

Action of homocarnosine, carnosine and anserine on uptake and metabolism of GABA in different subcellular fractions of rat brain

  • M. Tardy
  • B. Rolland
  • J. Bardakdjian
  • P. Gonnard
Specialia

Summary

L-Carnosine, L-homocarnosine and L-anserine are inhibitors of GABA metabolism. They show differential action on GABA-transaminase from synaptosomes compared to the extrasynaptosomal enzyme.

Keywords

Enzyme Carnosine Subcellular Fraction Differential Action Anserine 

Literatur

  1. 1.
    J.J. Pisano, J.D. Wilson, L. Cohen, D. Abraham and S. Udenfriend, J. biol. Chem.236, 499 (1961).PubMedGoogle Scholar
  2. 2.
    S.E. Severin, J.M. Bocharnikoua, P.L. Vul'fson, Yu.A. Grigorouich and G.A. Solov'eva, Biokhimiya28, 510 (1963).Google Scholar
  3. 3.
    R.H. Ng, F.D. Marshall, F.A. Henn and A. Sellstrom, J. Neurochem.28, 449 (1977).PubMedGoogle Scholar
  4. 4.
    M. Tardy, B. Rolland, C. Fages and P. Gonnard, Experientia32, 434 (1974).Google Scholar
  5. 5.
    M. Bloch-Tardy, B. Rolland and P. Gonnard, Biochimie56, 823 (1974).PubMedGoogle Scholar
  6. 6.
    Y. Yoshino, F.V. De Feudis and K.A.C. Elliott, Can. J. Biochem.48, 147 (1970).PubMedGoogle Scholar
  7. 7.
    E. Somoza, M.P. Pugnaire, L.M. Orensanz Muñoz, C.G. Portal, A.E. Ibañez and F.V. De Feudis, J. Neurochem.26, (1977).Google Scholar
  8. 8.
    E.G. Gray and U.P. Whittaker, J. Anat.96, 79 (1962).PubMedGoogle Scholar
  9. 9.
    M. Israel and P. Frachon Mastour, Archs Anat. microsc.59, 383 (1970).Google Scholar
  10. 10.
    O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).PubMedGoogle Scholar
  11. 11.
    I.A. Sytinsky and U.Y. Vasiliev, Enzymologia39, 1 (1969).Google Scholar
  12. 12.
    E. Roberts and D.G. Simonsen, Biochem. Pharmac.12 (2), 113 (1963).Google Scholar
  13. 13.
    Dixon, Biochem. J.129, 197 (1972).PubMedGoogle Scholar
  14. 14.
    Buu Nguyen and N.M. van Gelder, Can. J. Physiol.52, 674 (1973).Google Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • M. Tardy
    • 1
  • B. Rolland
    • 1
  • J. Bardakdjian
    • 1
  • P. Gonnard
    • 1
  1. 1.Département de BiochimieC.H.U. Henri-MondorCreteil-Cédex(France)

Personalised recommendations