Experientia

, Volume 52, Issue 9, pp 874–877 | Cite as

Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators

  • L. De Petrocellis
  • P. Orlando
  • M. Gavagnin
  • M. Ventriglia
  • G. Cimino
  • V. Di Marzo
Research Articles

Abstract

Five novel 1,2-sn-diacylglycerols with diterpenoid acyl moieties in thesn-1 position were isolated and characterized, together with the corresponding 1,3-sn-diacylglycerols, from three species of dorid nudibranchs molluscs. Their potent activity as morphogens in vivo in theHydra tentacle regeneration assay and their parallel activity as activators of rat brain protein kinase C (PKC) in vitro are reported here. Our findings promote the use of these compounds as useful molecular probes for both in vivo and in vitro studies on the participation of PKC in cell development.

Key words

Protein kinase C diacylglycerols Hydra marine natural products 

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Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • L. De Petrocellis
    • 1
  • P. Orlando
    • 2
  • M. Gavagnin
    • 4
  • M. Ventriglia
    • 3
  • G. Cimino
    • 4
  • V. Di Marzo
    • 4
  1. 1.Istituto di CiberneticaC.N.R.Arco Felice, Napoli(Italy)
  2. 2.Istituto di Biochimica delle Proteine ed EnzimologiaC.N.R.Arco Felice, Napoli(Italy)
  3. 3.Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di FarmaciaUniversità di NapoliNapoli(Italy)
  4. 4.Istituto per la Chimica di Molecole di Interesse BiologicoC.N.R.Arco Felice, Napoli(Italy)

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