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Effect of excision repair system on antibacterial and mutagenic activity of daunomycin and other intercalating agents inSalmonella typhimurium

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Summary

Daunomycin and adriamycin, are more mutagenic and antibacterial for a strain ofSalmonella typhimurium defective for theuvrB gene than for itsuvr+ counterpart. Other intercalating agents, as some acridine dyes, affect equally the two bacterial strains.

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Authors and Affiliations

  1. Istituto di Microbiologia dell' Università, Via Valerio 34, I-34127, Trieste, Italy

    B. Pani, C. Monti-Bragadin & L. Samer

Authors
  1. B. Pani
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  2. C. Monti-Bragadin
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  3. L. Samer
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Additional information

The authors thank Prof.B. N. Ames for supplying the strains ofSalmonella typhimurium and Dr.F. Quadrifoglio for many helpful discussions. This investigation was supported by fellowships given to two of us (B.P. and L.S.) by Fondazione C. & D. Callerio. The skilful technical assistance of Mrs.S. Saincich is also acknowledged.

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Pani, B., Monti-Bragadin, C. & Samer, L. Effect of excision repair system on antibacterial and mutagenic activity of daunomycin and other intercalating agents inSalmonella typhimurium. Experientia 31, 787–788 (1975). https://doi.org/10.1007/BF01938466

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  • DOI: https://doi.org/10.1007/BF01938466

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