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Alteration of erythrocyte (Na++K+)-ATPase by replacement of cholesterol by desmosterol in the membrane

  • Specialia Chimica, Biochimica
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Summary

Cholesterol of red blood cells (RBC) is readily exchanged by desmosterol and vice versa. The resulting alteration in the sterol composition influences the specific (Na++K+)-ATPase activity. It is suggested that this effect is due to an altered membrane fluidity.

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Authors and Affiliations

  1. Medizinische Poliklinik der Universität, Hospitalstrasse 3, D-69, Heidelberg, Germany

    W. Fiehn & D. Seiler

Authors
  1. W. Fiehn
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  2. D. Seiler
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Additional information

We are indebted toI. Geldmacher andH. Göttig for skilful technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, and the Sonderforschungsbereich 90 of the University of Heidelberg.

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Fiehn, W., Seiler, D. Alteration of erythrocyte (Na++K+)-ATPase by replacement of cholesterol by desmosterol in the membrane. Experientia 31, 773–775 (1975). https://doi.org/10.1007/BF01938456

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  • DOI: https://doi.org/10.1007/BF01938456

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