Summary
The occurrence from a marine sponge of 4-hydroxyphenylpyruvic acid oxime is good evidence that an oxime (4) is the biogenetic precursor of aerothionin (1), homoaerothionin (2) and aeroplysinin-1 (3), brominated metabolites isolated from Verongia sponges.
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Literatur
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We are grateful to the Station Biologique de Roscoff (Nord-Finistère, France) for their hospitality which enabled us to collect the sponge.
Difficulty was experienced in purification of the natural compound because its facile conversion to thep-hydroxyphenylacetic acid.
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Cimino, G., de Stefano, S. & Minale, L. Occurrence of 4-hydroxyphenylpyruvic acid oxime in the marine spongeHymeniacidon sanguinea. Experientia 31, 756–757 (1975). https://doi.org/10.1007/BF01938443
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DOI: https://doi.org/10.1007/BF01938443