, Volume 32, Issue 2, pp 183–184 | Cite as

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives

  • J. G. Meingassner
  • H. Mieth


The strainT. foetus KV 1/M 100, a sub-strain ofT. foetus Kv 1, was made highly resistant to metronidazole by several passages in mice under increasing drug pressure. This drug resistance was accompained by a remarkable cross-resistance to all 5-nitroimidazole-derivatives tested in vitro and in vivo.


Drug Resistance Metronidazole Drug Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    R. Samuels, J. Protozool.8, 5 (1961).Google Scholar
  2. 2.
    B. M. Honigberg andM. C. Livingston, inProc. First Int. Congress of Parasitology (Ed.A. Corradetti, Pergamon Press, Oxford 1966) vol. 1, p. 365.Google Scholar
  3. 3.
    I. de Carneri, inProc. First International Congress of Parasitology (Ed.A. Corradetti; Pergamon Press, Oxford 1966), vol. 1, p. 366.Google Scholar
  4. 4.
    P. Actor, D. S. Ziv, J. F. Pagano, Science164, 439 (1969).PubMedGoogle Scholar
  5. 5.
    F. Benazet andL. Guillaume, Lancet2, 982 (1971).Google Scholar
  6. 6.
    I. de Carneri andF. Trane, Arzneimittel Forsch. (Drug Res.)21, 377 (1971).Google Scholar
  7. 7.
    Compounds not available on the market were kindly supplied by the corresponding pharmaceutical firms.Google Scholar
  8. 8.
    The strain KV 1 was kindly provided byJ. Kulda, Prague, 1970.Google Scholar
  9. 9.
    D. K. McLoughlin, J. Parasit.53, 646 (1967).PubMedGoogle Scholar
  10. 10.
    I. de Carneri, Trans. R. Soc. trop. Med. Hyg.65, 268 (1971).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • J. G. Meingassner
    • 1
  • H. Mieth
    • 1
  1. 1.Sandoz Forschungsinstitut Gesellschaft m.b.H.Wien(Austria)

Personalised recommendations