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Roquefortine and isofumigaclavine A, metabolites fromPenicillium roqueforti

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Summary

The structures of two metabolites fromPenicillium roqueforti, designated roquefortine and isofumigaclavine A, have been determined by chemical and spectroscopic studies.

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References

  1. Acknowledgements. We thankS. Moreau for mycelium ofP. roqueforti andJ.-C. Gripon and MlleE. Zissmann for additional cultures;B. Septe for13C nmr-spectra:S. K. Kan for the 240 MHz1H nmr-spectrum of roquefortine; MmeLe Phan Diêp for amino acid analyses; andS. Wilkinson andP. G. Mantle, respectively, for samples of fumigaclavine B and agroclavine.

  2. J. F. Spilsbury andS. Wilkinson, J. chem. Soc.1961, 2085.

  3. By high resolution mass spectroscopy, courtesy ofP. Varenne, W. B. Turner andW. F. Miles. We thankB. C. Das for helpful discussion.

  4. N. K. Hart, S. R. Johns, J. A. Lamberton andR. E. Summons, Aust. J. Chem.27, 639 (1974).

    Article  CAS  Google Scholar 

  5. A. Ahond, M.-M. Janot, N. Langlois, G. Lukacs, P. Potier, P. Rasoanaivo, M. Sangaré, N. Neuss, M. Plat, J. Le Men, E. W. Hagaman andE. Wenkert, J. Am. Chem. Soc.96, 633 (1974).

    Article  CAS  Google Scholar 

  6. S. Sape andA. Taylor, J. chem. Soc. Perkin I1972, 472.

  7. D. W. Nagel, K. G. R. Pachler, P. S. Steyn, P. L. Wessels, G. Gafner andG. J. Kruger, J. chem. Soc., Chem. Commun.1974, 1021.

  8. P. S. Steyn, personal communication.

  9. W. D. Jamieson, R. Rahman andA. Taylor, J. chem. Soc. (C)1969, 1564.

  10. H. Minato, M. Matsumoto andT. Katayama, J. chem. Soc. Perkin I1973, 1819.

  11. D. Hauser, H. P. Weber andH. P. Sigg, Helv. chim. Acta53, 1061 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. N. J. Bach, H. E. Boaz, E. C. Kornfeld, C.-J. Chang, H. G. Floss, E. W. Hagaman andE. Wenkert, J. org. Chem.39, 1272 (1974).

    Article  CAS  PubMed  Google Scholar 

  13. Experiments carried out at the Institut de Recherches Scientifiques sur le Cancer, Villejuif, France byC. Frayssinet andChristiane Frayssinet showed that the LD50 (i.p., male mice) was 15–20 mg/kg. Doses of 50–100 mg/kg caused prostration and an atonic posture. The prostration would be interrupted for a few seconds by opisthotonoid seizures which could be brought about by noise or a tap on the cage. Death followed within a few hours. At doses of 10 mg/kg convulsions were replaced by simple contractions and the state of prostration by equilibrium disorders during movement.

  14. S. Ohmomo, T. Sato, T. Utagawa andM. Abe Agric. biol. Chem.39, 1333 (1975).

    CAS  Google Scholar 

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Scott, P.M., Merrien, MA. & Polonsky, J. Roquefortine and isofumigaclavine A, metabolites fromPenicillium roqueforti. Experientia 32, 140–142 (1976). https://doi.org/10.1007/BF01937728

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