, Volume 32, Issue 11, pp 1475–1476 | Cite as

Effects of antithymic reticuloepithelial cells serum on the levels of circulating thymic factor and on the sensitivity to azathioprine of spleen spontaneous rosette-forming cells

  • E. Garaci
  • Vera del Gobbo
  • Cristina Rinaldi-Garaci
Haematologica, Immunologica


Swiss mice treated with an antithymic reticuloepithelial cells serum (ATRES) showed a drastic and prolonged depression of the serum thymic factor. A similar but less pronounced effect was also observed following the administration of the antithymocyte (ATS) and the antilymphocyte (ALS) sera. Conversely, the azathioprine sensitivity of spleen spontaneous rosette-forming cells was highly modified by the ATRES but not by the ATS or the ALS. The probable mechanisms of such effects are discussed.


Depression Pronounced Effect Probable Mechanism Swiss Mouse Azathioprine Sensitivity 
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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • E. Garaci
    • 1
    • 2
  • Vera del Gobbo
    • 1
    • 2
  • Cristina Rinaldi-Garaci
    • 1
    • 2
  1. 1.Institute of MicrobiologyCatania UniversityCataniaItaly
  2. 2.Institute of General Biology dell' UniversitàRomaItaly

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