Experientia

, Volume 34, Issue 5, pp 619–621 | Cite as

Electrogenic hyperpolarization in canine cardiac Purkinje fibres exposed to calcium ionophores

  • J. M. Gelles
  • R. Zeiler
Article
  • 8 Downloads

Summary

The Ca ionophores markedly enhance the increase of intracellular Ca occurring during Na-free perfusion and the hyperpolarization observed upon Na readmission may be due to rapid restoration of intracellular Na and resultant stimulation of both electrogenic sodium and calcium efflux.

Keywords

Sodium Calcium Calcium Ionophore Purkinje Fibre Rapid Restoration 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 2.
    H. Reuter and N. Seitz, J. Physiol.195, 451 (1968).PubMedGoogle Scholar
  2. 3.
    I.R. Wendt and G.A. Langer, J. molec. cell. Cardiol.9, 551 (1977).Google Scholar
  3. 4.
    H. Jundt, H. Porzig, H. Reuter and J.W. Stucki, J. Physiol.246, 229 (1975).PubMedGoogle Scholar
  4. 5.
    J.M. Gelles, Experientia32, 906 (1976).PubMedGoogle Scholar
  5. 6.
    J.M. Gelles, Circulation Res.41, 94 (1977).PubMedGoogle Scholar
  6. 7.
    P.W. Reed and H.A. Lardy, J. biol. Chem.247, 6970 (1972).PubMedGoogle Scholar
  7. 8.
    C.M. Armstrong and B. Hille, J. gen. physiol.59, 388 (1972).PubMedGoogle Scholar
  8. 9.
    J.J. Van Der Walt and E. Carmeliet, Archs int. Physiol. Biochem.79, 149 (1971).Google Scholar
  9. 10.
    D.S. Miura, B.F. Hoffman and M.R. Rosen, J. gen. Physiol.69, 463 (1977).CrossRefPubMedGoogle Scholar
  10. 11.
    B.C. Pressman and N.T. deGuzman, Ann. N.Y. Acad. Sci.264, 373 (1975).PubMedGoogle Scholar
  11. 12.
    H. Reuter, Prog. Biophys. molec. Biol.26, 3 (1973).CrossRefGoogle Scholar
  12. 13.
    J.M. Marshall and E.A. Kroeger, Phil. Trans. R. Soc. Lond. B265, 135 (1973).Google Scholar
  13. 14.
    J.R. Wiggins and P.F. Cranefield, J. gen. Physiol.64, 473 (1974).CrossRefPubMedGoogle Scholar
  14. 15.
    H.G. Haas, in: Electrical Phenomena in the Heart, p. 163. Academic Press, London 1972.Google Scholar
  15. 16.
    J.B. Bassinghthwaighte, C.H. Fry and J.A.S. McGuigan, J. Physiol.262, 15 (1976).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • J. M. Gelles
    • 1
  • R. Zeiler
    • 1
  1. 1.Department of MedicineDownstate Medical Center of the State University of New YorkBrooklynUSA

Personalised recommendations