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Depression by ethionine of phosphorylating oxidation in hepatic mitochondria

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Summary

Induction of hepatic steatosis and suppression of hepatic ATP levels, protein synthesis and gluconeogenesis subsequent to administration of ethionine may be consequences of interference by this compound with mitochondrial phosphorylation of ADP. The mitochondrial dysfunction is not a direct action of ethionine on the organelle.

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Authors and Affiliations

  1. Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    E. S. Higgins, W. H. Friend & K. S. Rogers

Authors
  1. E. S. Higgins
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  2. W. H. Friend
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  3. K. S. Rogers
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Higgins, E.S., Friend, W.H. & Rogers, K.S. Depression by ethionine of phosphorylating oxidation in hepatic mitochondria. Experientia 34, 578–579 (1978). https://doi.org/10.1007/BF01936969

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