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Inhibition of DNA synthesis in BHK fibroblasts treated in vitro with potassium dichromate

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Summary

Treatment of hamster fibroblasts with potassium dichromate in vitro stimulates tritiated thymidine uptake into the intracellular nucleotide pool. This effect is due to the oxidizing action of hexavalent chromium on the plasma membrane. Dichromate induces also an inhibition of DNA replication, which is due to the interaction of reduced trivalent chromium with specific biological ligands on the DNA molecule.

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References

  1. A. Furst andR. T. Haro, Progr. Exp. Tumor Res.12, 102 (1969).

    Article  CAS  PubMed  Google Scholar 

  2. E. C. Miller andJ. A. Miller, inChemical Mutagens, vol. 1 (Ed. A. Holmaender; Plenum Press, New York 1971), p. 83.

    Chapter  Google Scholar 

  3. H. Nishioka, Mutation Res.31, 185 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. E. Browning, inToxicity of Industrial Metals (Butterwords, London 1969), p. 119.

    Google Scholar 

  5. I. A. R. C. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, vol. 2 (Int. Agency Res. Cancer, Lyon 1973), p. 100.

    Google Scholar 

  6. G. Maltoni, Excerpta Med. int. Congr. Ser.322, 1 (1974).

    Google Scholar 

  7. E. Gläss, Z. Bot.44, 1 (1956).

    Google Scholar 

  8. S. Venitt andL. S. Levy, Nature, Lond.250, 493 (1974).

    Article  CAS  PubMed  Google Scholar 

  9. M. Tamaro, E. Banfi, S. Venturini andC. Monti-Bragadin, XVII Congr. It. Microbiol. Soc., (1976), p. 411.

  10. S. Bonatti, M. Meini andA. Abbondandolo, Mutation Res.38, 147 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. A. Fradkin, A. Janoff, B. P. Lane andM. Kuschner, Cancer Res.35, 1058 (1975).

    CAS  PubMed  Google Scholar 

  12. J. W. Huff, K. S. Sastry, M. P. Gordon andW. E. C. Wacker, Biochemistry3, 501 (1964).

    Article  CAS  PubMed  Google Scholar 

  13. W. Mertz, Physiol. Rev.49, 163 (1969).

    Article  CAS  PubMed  Google Scholar 

  14. R. Schoental, Br. J. Cancer32, 403 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. A. G. Levis, M. Buttignol, Brit. J. Cancer, in press.

  16. P. V. Hauschka, inMethods in Cell Biology, vol. 7 (Ed. D. M. Prescott; Academic Press, New York 1973), p. 361.

    Google Scholar 

  17. G. Tamino, Atti Ass. Genet. It., in press.

  18. This work was supported by a grant from the National Research Council of Italy.

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Authors and Affiliations

  1. Institute of Animal Biology, University of Padova, Via Loredan 10, I-35100, Padova, Italy

    A. G. Levis, M. Buttignol & L. Vettorato

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  1. A. G. Levis
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  2. M. Buttignol
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  3. L. Vettorato
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Levis, A.G., Buttignol, M. & Vettorato, L. Inhibition of DNA synthesis in BHK fibroblasts treated in vitro with potassium dichromate. Experientia 33, 82–84 (1977). https://doi.org/10.1007/BF01936767

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