Experientia

, Volume 33, Issue 1, pp 55–57 | Cite as

7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide a new antihypertensive agent

  • M. Shimizu
  • K. Yoshida
  • T. Kadokawa
  • N. Hatano
  • J. Kuwashima
  • K. Nakatsuji
  • I. Nose
  • M. Kobayashi
Article

Summary

7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) is a new compound having sustained antihypertensive activity in a similar manner to that of hydrochlorothiazide. However, this compound shows neither diuretic nor hyperglycemic effect, being different from those of hydrochlorothiazide or diazoxide.

Keywords

Dioxide Hydrochlorothiazide Antihypertensive Agent Diazoxide Antihypertensive Activity 

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References

  1. 1.
    K. Okamoto and K. Aoki, Jap. Cireul. J.27, 282 (1963).Google Scholar
  2. 2.
    O. H. Lowry, J. V. Passonneau, F. X. Hasselberger and D. W. Schulz, J. biol. Chem.239, 18 (1964).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • M. Shimizu
    • 1
  • K. Yoshida
    • 1
  • T. Kadokawa
    • 1
  • N. Hatano
    • 1
  • J. Kuwashima
    • 1
  • K. Nakatsuji
    • 1
  • I. Nose
    • 1
  • M. Kobayashi
    • 1
  1. 1.Department of Pharmacology, Research LaboratoriesDainippon Pharmaceutical Co., Ltd.Suita, Osaka(Japan)

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