, Volume 46, Issue 8, pp 868–869 | Cite as

Vascular reactivity in chronic Goldblatt two kidney-one clip hypertensive rats

  • J. Duarte
  • J. Andrade
  • F. Vargas
Research Articles


We studied the possible contribution of increased vascular reactivity in the chronic phase of Goldblatt two kidney-one clip hypertension. Vascular reactivity was evaluated in aortic strips from hypertensive rats (16 weeks after inducing hypertension) and age-matched control rats. The findings were: a) increased sensitivity to vasopressin in the aortic tissue of hypertensive rats, b) a similar response to angiotensin II, noradrenaline and KCl in hypertensive and control rats, and c) reduced maximal response to angiotensin II compared with other vasoconstrictors in both groups of rats. These results suggest a possible role for vasopressin in the chronic phase of this model of hypertension.

Key words

Goldblatt two kidney-one clip hypertension vascular reactivity noradrenaline vasopresin angiotensin 


  1. 2.
    Ferrario, C. M., Am. J. Physiol.226 (1974) 711.PubMedGoogle Scholar
  2. 3.
    Lundgren, Y., Hallback, M., Weiss, L., and Folkow, B., Acta physiol. scand.91 (1974) 103.PubMedGoogle Scholar
  3. 4.
    Ono, Z., Prewitt, R. L., and Stacy, D. L., Hypertension14 (1989) 36.PubMedGoogle Scholar
  4. 5.
    Freeman, R. H., Davis, J. O., Watkins, B. E., Stephens, G. A., and De Forrest, J. M., Am. J. Physiol.236 (1979) F21.PubMedGoogle Scholar
  5. 6.
    Zimmermann, B. G., Circ. Res.53 (1983) 121.PubMedGoogle Scholar
  6. 7.
    Bandick, M. R., and Sparks, H. V., Am. J. Physiol.291 (1970) 340.Google Scholar
  7. 8.
    Holloway, E. T., and Bohr, D. F., Circ. Res.33 (1973) 678.PubMedGoogle Scholar
  8. 9.
    Couture, R., and Regoli, D., Clin. exp. Hypertens.2 (1980) 45.PubMedGoogle Scholar
  9. 10.
    Aoki, K., and Masson, G. M. C., Nephron6 (1969) 484.PubMedGoogle Scholar
  10. 11.
    Folkow, B., Hallback, M., Lundgren, Y., Silverstsson, R., and Weiss, L., Circ. Res.32, suppl. I (1973) I-2.Google Scholar
  11. 12.
    Lever, A. F., J. Hypertens.4 (1986) 515.PubMedGoogle Scholar
  12. 13.
    Owens, G. K., and Schwartz, S. M., Circ. Res.53 (1983) 491.PubMedGoogle Scholar
  13. 14.
    Share, L., and Crofton, J. T., Hypertension4, suppl. III (1982) III-85.Google Scholar
  14. 15.
    Vargas, F., Casanova, I., Haro, J. M., Luna, J. D., and Garcia del Rio, C., Horm. Metab. Res.22 (1990) 352.PubMedGoogle Scholar
  15. 16.
    Mohring, J., Klin. Wochenschr.56, suppl. I (1978) 71.CrossRefPubMedGoogle Scholar
  16. 17.
    Rabito, S., Carretero, O. A., and Scicli, A. G., Hypertension3 (1981) 34.PubMedGoogle Scholar
  17. 18.
    Marks, E. S., Bing, R. F., Thurstom, H., Russell, G. I., and Swales, J. D., Hypertension4 (1982) 238.PubMedGoogle Scholar
  18. 19.
    Skulan, T. W., Brousseau, A. C., and Leonard, K. A., Circ. Res.35 (1974) 734.PubMedGoogle Scholar
  19. 20.
    Collis, M. G., and Vanhoutte, P. M., Circ. Res.41 (1977) 759.PubMedGoogle Scholar
  20. 21.
    Berecek, K. H., Murray, R. D., Gross, F., and Brody, M. J., Hypertension4 (1982) 3.Google Scholar
  21. 22.
    Couture, R., and Regoli, D., Clin. exp. Hypertens.2 (1980) 1.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1990

Authors and Affiliations

  • J. Duarte
    • 1
  • J. Andrade
    • 1
  • F. Vargas
    • 1
  1. 1.Departamento de Bioquimica y Biologia MolecularFacultad de MedicinaGranadaSpain

Personalised recommendations