Summary
Wistar rats show a circadian variation in their response to stress. Pinealectomy exacerbates stress-induced gastric ulceration in rats. This effect is counteracted by melatonin administration.
Similar content being viewed by others
References
The authors would like to thank Mrs S. Morley for her technical assistance.
This work was supported by grants from the Medical Research Council of South Africa and the Rhodes University Council to Professor B. Potgieter.
Axelrod, J., Science184 (1974) 1341.
Minneman, K. P., and Wurtman, R. J., Life Sci.17 (1984) 1189.
Vaughan, G. M., Allen, J. P., Tullis, W., Sackman, J. W., and Vaughan, M. K., Neurosci. Lett.91 (1978) 83.
Lynch, H. J., Eng, J. P., and Wurtman, R. J., Proc. natl Acad. Sci.70 (1973) 227.
Tannenbaum, M. G., Reiter, R. J., Vaughan, M. K., Troiani, M. E., and Gonzalez-Brito, A., Cryobiology25 (1988) 227.
Miline, R., J. neural Trans.47 (1980) 191.
Romijn, H. J., Life Sci.23 (1978) 2257.
Mehdi, A. Z., and Sandor, T., J. Steroid Biochem.8 (1977) 821.
Dickson, K. L., and Hasty, D. L., Acta endocr.70 (1972) 438.
Pare, W. P., and Glavin, G. B., Neurosci. Biobehav. Rev.10 (1986) 339.
Maestroni, G. J. M., Conti, A., and Pierpaoli, W., Immunology63 (1988) 465.
Senay, E. C., and Levine, R. J., Proc. Soc. exp. Med.124 (1967) 1221.
Khan, R., Burton, S., Morley, S., Daya, S., and Potgieter, B., Experientia46 (1990) 88.
Hoffman, R. A., and Reiter, R. J., Anat Rec.153 (1965) 19.
Reiter, R. J., (ed.), The Pineal Gland, vol. 111, Extra Reproductive Effects, pp. 90–96. CRC Press, Florida 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Khan, R., Daya, S. & Potgieter, B. Evidence for a modulation of the stress response by the pineal gland. Experientia 46, 860–862 (1990). https://doi.org/10.1007/BF01935539
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01935539