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Changes in brain acetylcholinesterase activity of young rats after chronic treatment with tremorine

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Résumé

La trémorine a été administrée chez les rats quotidiennement pendant 7 jours à des doses de 7.5, 22.5 ou 30 mg/kg. Les témoins ont montré des mouvements convulsifs proportionnels à la dose de trémorine. Quatre jours après l'arrêt du traitement, l'activité acétylcholinestérasique du cortex cérébral était augmentée. Il est proposé que ce change de l'activité acétylcholinestérasique reflète une utilisation accrue de l'acétylcholine corticale.

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Authors and Affiliations

  1. Departments of Psychiatry and Pharmacology, University of Colorado of School Medicine, 80220, Denver, Colorado, USA

    Antonia Vernadakis

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  1. Antonia Vernadakis
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Additional information

Acknowledgement: This investigation was supported by a U.S. Public Health Service Grant No. NS 09199 and a Research Scientist Development Award No. K02 MH-42479 from the National Institute of Mental Health, National Institutes of Health.

The author gratefully acknowledges the technical assistance ofSandra Roland.

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Vernadakis, A. Changes in brain acetylcholinesterase activity of young rats after chronic treatment with tremorine. Experientia 29, 1257–1259 (1973). https://doi.org/10.1007/BF01935105

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