Resumen
Varias drogas anti-inflamatorias incluyendo una droga antiinflamatoria no esteroidea nueva fueron investigadas en heridas producidas en ratas. AHR-1911 resultó ser la droga menos depresora de la cicatrización de las heridas cuando se comparó con la fenilbutazona y la dexametasona. Un menor contenido de colágeno en las heridas fue observado con el uso de AHR-1911.
Literatur
E. W. Rosenberg, Archs Derm.104, 632 (1971).
C. A. Schlagel andJ. I. Northam, Proc. Soc. exp. Biol. Med.101, 629 (1959).
E. L. Howes, C. M. Plotz, J. W. Blunt andC. Ragan, Surgery28, 177 (1950).
H. P. Ehrlich andK. H. Thomas, Ann. Surg.167, 324 (1968).
N. Ercoli, J. Arbona andE. Tabernero, Proc. Soc. exp. Biol. Med.136, 1328 (1971).
C. J. Riobueno, Curr. ther. Res.12, 718 (1970).
J. Di Prisco, Curr. ther. Res.11, 634 (1969).
P. Sandblom, P. Petersen andA. Muren, Acta chir. scand.105, 252 (1953).
M. Velasco yE. Romero, Acta cient. venez.21, Suppl 1, 38 (1970).
N. Sandberg andB. Zederfeldt, Acta chir. scand.126, 182 (1963).
C. Mitoma, T. E. Smith, J. D. Davidson, S. Udenfriend, F. M. Da Costa andA. Sjoerdsma, J. clin. Lab. Med.53, 970 (1959).
G. W. Snedecor andW. G. Cochran.Statistical methods, 6th edn. (Iowa State University Press, Iowa City 1971).
B. M. Sorensen, inHormones and Connective Tissue (Ed.G. Asboe-Hansen; Williams and Wilkins, Baltimore 1966), p. 106.
G. Weissman, Biochem. Pharmac.14, 525 (1965).
J. C. Houck, J. Johnston andR. A. Jacob, Biochem. Pharmac.17, Suppl., 69 (1968).
E. W. Dempsey andA. I. Lansing, inInternational Review of Cytology (Ed.G. H. Bourne andJ. F. Danielli; Academic Press, Inc., New York 1954) vol. 3, p. 437.
Author information
Authors and Affiliations
Additional information
This study was in part presented at IV Latin-american Congress on Pharmacology and Therapeutics, Caracas, Venezuela, July 9–14, 1972.
AHR-1911 was kindly supplied by ProfessorN. Ercoli. Dexamethasone and phenylbutazone were supplied by Merck Sharp and Dohme and Geigy Laboratories, respectively, Caracas, Venezuela.
Rights and permissions
About this article
Cite this article
Velasco, M., Guaitero, E. A comparative study of some anti-inflammatory drugs in wound healing of the rat. Experientia 29, 1250–1251 (1973). https://doi.org/10.1007/BF01935101
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01935101