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Conformation and toxicity of amanitins

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Zusammenfassung

Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekühls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere. Die absolute Konfiguration der Sulfoxidgruppe der Amatoxine ist identisch mit der des toxischen Phalloidinsulfoxids.

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Literatur

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Authors and Affiliations

  1. Abteilung Chemie, Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69, Heidelberg, Germany

    H. Eaulstich, M. Bloching, S. Zobeley & Th Wieland

Authors
  1. H. Eaulstich
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  2. M. Bloching
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  3. S. Zobeley
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  4. Th Wieland
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Additional information

Part 43 of the series: Components of the green deathcap toadstoolAmanita phalloides. Part 42:F. Fahrenholz, H. Faulstich andTh. Wieland, Liebigs Annln Chem.743, 83 (1971).

Acknowledgment. The authors wish to express their gratitude toDr. A. Buku for preparation of methyl-α-aldoamanitin.

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Eaulstich, H., Bloching, M., Zobeley, S. et al. Conformation and toxicity of amanitins. Experientia 29, 1230–1232 (1973). https://doi.org/10.1007/BF01935088

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