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Cholesterol oxidation by rat liver preparations: Effect of age

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Résumé

On a constaté que les vieux rats synthétisent moins de cholestérine et qu'ils excrètent moins de stéroides acides que les jeunes. Nous avons comparé l'activité de deux systèmes d'enzymes hépatiques chez les jeunes et les vieux rats. Ces systèmes sont la préparation microsomale qui comprend l'activité de la cholestérine 7α-hydroxylase, et la préparation mitochondrique qui parvient à oxyder [26-14C] de cholestérine à14CO2. Les deux systèmes qui entrent en jeu dans la synthèse des acides de la bile sont significativement plus actifs dans le foie des jeunes rats.

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  10. Supported, in part, by Public Health Service Research Grant No. HL-03299 and Research Career Award No. HL-00734 from the National Heart and Lung Institute, No. RR-05540 from the Division of Research Resources, No. GM-00142 from Nat. Inst. of Gen. Med. Sciences, and funds from the Commonwealth of Pennsylvania.

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Authors and Affiliations

  1. Wistar Institute of Anatomy and Biology, 36th Street at Spruce, 19104, Philadelphia, Pennsylvania, USA

    J. A. Story & D. Kritchevsky

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  1. J. A. Story
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  2. D. Kritchevsky
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Story, J.A., Kritchevsky, D. Cholesterol oxidation by rat liver preparations: Effect of age. Experientia 30, 242–243 (1974). https://doi.org/10.1007/BF01934803

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