Skip to main content
SpringerLink
Log in

Inhibition of beef heart and rat brain nucleoside-3′:5′-monophosphate phosphodiesterase by 3β-14-dihydroxy-21-oxo-23-desoxo-5-β-card-20(22)-enolide 3-acetate (AY-17,605) and structurally related compounds

  • Published:
Experientia Aims and scope Submit manuscript

Résumé

Des composés isomères aux glycosides cardiaques naturels ont démontré l'inhibition in vitro de l'enzyme nucleoside-3′:5′-monophosphate phosphodiesterase (PDE) d'origine cœur du bœuf exercée sur le cyclic-AMP, le composé le plus actif étant un dérivé de la lactone isomérique contenant une fraction 3-acetyl (AY-17,605); leK i du composé AY-17,605 était de 0.64×10−4 M et le procédé inhibiteur était d'une nature non-compétitive. Aucun des composés n'a exhibé une activité supérieure autre qu'une inhibition modérée du PDE dans le cerveau du rat.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Rerefences

  1. G. A. Robison, R. W. Butcher andE. W. Sutherland, A. Rev. Biochem.37, 149 (1968).

    Article  CAS  Google Scholar 

  2. G. Beaulieu, Can. Fedn. biol. Soc.15, abstr. 68 (1972).

  3. G. Brooker, L. J. Thomas Jr., andM. M. Appleman., Biochemistry7, 4177 (1968).

    Article  CAS  Google Scholar 

  4. A. R. Somerville, M.-L. Rabouhans andA. A. Smith, Biochem. J.120, 11P (1970).

  5. O. H. Lowry, N. J. Rosebrough, A. L. Farr andR. J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  Google Scholar 

  6. H. Lineweaver andD. Burk, J. Am. chem. Soc.56, 658 (1934).

    Article  CAS  Google Scholar 

  7. M. Dixon, Biochem. J.55, 170 (1953).

    Article  CAS  Google Scholar 

  8. K. G. Nair, Biochemistry5, 150 (1966).

    Article  CAS  Google Scholar 

  9. O. M. Rosen, Arch. Biochem. Biophys.137, 435 (1970).

    Article  CAS  Google Scholar 

  10. W. Y. Cheung, Biochemistry6, 1079 (1967).

    Article  CAS  Google Scholar 

  11. F. Honda andH. Imamura, Biochim. biophys. Acta161, 267 (1968).

    Article  CAS  Google Scholar 

  12. H. Sheppard andG. Wiggan, Molec. Pharmac.7, 111 (1971).

    CAS  Google Scholar 

  13. W. A. Pettinger, M. W. Osborne andR. A. Moe, Pharmacologist11, 289 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemical Pharmacology Department, Ayerst Laboratories, P.O. Box 6115, Montreal, Quebec, Canada

    W. Lippmann

Authors
  1. W. Lippmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. The author wishes to acknowledge the technical assistance of MissG. Carew-Gibson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lippmann, W. Inhibition of beef heart and rat brain nucleoside-3′:5′-monophosphate phosphodiesterase by 3β-14-dihydroxy-21-oxo-23-desoxo-5-β-card-20(22)-enolide 3-acetate (AY-17,605) and structurally related compounds. Experientia 30, 237–239 (1974). https://doi.org/10.1007/BF01934800

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01934800

Keywords

Search

Navigation