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A radioautographic study on the mechanisms by which adrenal glucocorticoids play their permissive role in the biological activity of cyclic AMP in the liver cell

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I meccanismi che operano alla base dell'effetto «permissivo» dei corticosteroidi sulle azioni metaboliche dell'adenosin-monofosfato-3′,5′-ciclico (cAMP) sono stati indagati in colture primarie di fegato di Ratto. I risultati ottenuti indicano che i glucocorticoidi, mentre diminuiscono l'utilizzazione del cAMP nel nucleo degli epatociti, la aumentano a livello del citoplasma. Viene avanzata l'ipotesi che gli steroidi inibiscano la sintesi delle chinasi proteiche nucleari cAMP-dipendenti e/o il loro trasferimento nel nucleo e, contemporaneamente, stimolino la sintesi delle chinasi citoplasmatiche. Per converso, si è appurato, in parallelo, che il cAMP ha effetti alquanto limitati sul destino del cortisolo (e metaboliti) legato a proteine nella cellula epatica.

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Authors and Affiliations

  1. Tissue Culture Laboratory of the Department of Human Anatomy, University of Padova Medical School, Via A. Gabelli 37, Padova, Italy

    U. Armato, Enrica Draghi & Paola G. Andreis

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  1. U. Armato
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  2. Enrica Draghi
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  3. Paola G. Andreis
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Armato, U., Draghi, E. & Andreis, P.G. A radioautographic study on the mechanisms by which adrenal glucocorticoids play their permissive role in the biological activity of cyclic AMP in the liver cell. Experientia 30, 230–232 (1974). https://doi.org/10.1007/BF01934796

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  • DOI: https://doi.org/10.1007/BF01934796

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