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Synthesis and some characteristics of [13C]-specially enriched tetragastrin and the related compound

Experientia volume 33, pages 1566–1567 (1977)Cite this article

Summary

[13C]-enriched tetragastrin and the related compound were synthesized in solution. Conversion of S-[13C]-methylated tetragastrin to the enriched tetragastrin gave 10.5 ppm upfield chemical shift of Cɛ resonance. The potency of the synthetic tetragastrin to stimulate gastric acid secretion was virtually identical with that of pentagastrin (ICI).

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Author notes

  1. S. Yamada

    Present address: Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi, 602, Kamigyo-ku, Kyoto, (Japan)

Affiliations

  1. Shizuoka College of Pharmacy, Oshika, 422, Shizuoka, (Japan)

    S. Yamada, M. Sakagami, N. Yanaihara, H. Nishikawa & H. Watari

  2. Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi, 602, Kamigyo-ku, Kyoto, (Japan)

    M. Sakagami, N. Yanaihara, H. Nishikawa & H. Watari

Authors
  1. S. Yamada
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  2. M. Sakagami
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  3. N. Yanaihara
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  4. H. Nishikawa
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  5. H. Watari
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Additional information

Acknowledgment. A part of this research was supported by scientific research funds (No. 944059, 048253) from the Japanese Ministry of Education.

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Yamada, S., Sakagami, M., Yanaihara, N. et al. Synthesis and some characteristics of [13C]-specially enriched tetragastrin and the related compound. Experientia 33, 1566–1567 (1977). https://doi.org/10.1007/BF01933999

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  • DOI: https://doi.org/10.1007/BF01933999

Keywords

  • Methylated
  • Chemical Shift
  • Gastric Acid
  • Acid Secretion
  • Related Compound