, Volume 32, Issue 1, pp 83–84 | Cite as

Effect of colchicine on polymerization of tubulin from rats, mice, hamsters and guinea-pigs

  • T. J. Fitzgerald
  • D. G. Mayfield


Colchicine-inhibition of polymerization of tubulin from rats, mice, golden hamsters and guinea-pigs was studied to determine if species differences in tubulin sensitivity to colchicine might parallel species variation in colchicine toxicity. It was found that polymerization of tubulin is nearly equally sensitive to colchicine in all four species.


Polymerization Toxicity Species Variation Colchicine Species Difference 


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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • T. J. Fitzgerald
    • 1
  • D. G. Mayfield
    • 1
  1. 1.School of PharmacyFlorida A & M UniversityTallahasseeUSA

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