Experientia

, Volume 32, Issue 1, pp 83–84 | Cite as

Effect of colchicine on polymerization of tubulin from rats, mice, hamsters and guinea-pigs

  • T. J. Fitzgerald
  • D. G. Mayfield
Specialia

Summary

Colchicine-inhibition of polymerization of tubulin from rats, mice, golden hamsters and guinea-pigs was studied to determine if species differences in tubulin sensitivity to colchicine might parallel species variation in colchicine toxicity. It was found that polymerization of tubulin is nearly equally sensitive to colchicine in all four species.

Keywords

Polymerization Toxicity Species Variation Colchicine Species Difference 

References

  1. 2.
    M. Orsini andB. Pansky, Science115, 88 (1952).PubMedGoogle Scholar
  2. 3.
    A. Hunter andC. Klaassen, J. Pharmac. exp. Ther.192, 605 (1975).Google Scholar
  3. 4.
    M. Schönhartung, G. Mende andG. Siebert, Hoppe-Seyler's Z. physiol. Chem.355, 1391 (1974).PubMedGoogle Scholar
  4. 5.
    A. R. Midgeley, B. Pierce andF. J. Dixon, Science130, 40 (1959).PubMedGoogle Scholar
  5. 6.
    R. F. Itzhaki andD. M. Gill, Analyt. Biochem.9, 401 (1964).CrossRefGoogle Scholar
  6. 7.
    J. B. Olmsted andG. G. Borisy, Biochemistry12, 4282 (1973).CrossRefPubMedGoogle Scholar
  7. 8.
    W. Fleischmann, O. Q. Russell andS. K. Fleishmann, Med. exp.6, 101 (1962).PubMedGoogle Scholar
  8. 9.
    C. D. Barnes andG. L. Eltherington,Drug Dosage in Laboratory Animals. A Handbook (University of California Press, Berkeley, Calif. 1966), p. 73.Google Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • T. J. Fitzgerald
    • 1
  • D. G. Mayfield
    • 1
  1. 1.School of PharmacyFlorida A & M UniversityTallahasseeUSA

Personalised recommendations