Skip to main content
SpringerLink
Log in

Flashing phenomenon in blood platelets stained with fluorescent basic drugs

  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Nach Behandlung von Blutplättchen mit Mepacrin, Acridin-Orange und Daunomycin, die sich selektiv in den 5-Hydroxytryptamin- (5HT)-Speicher-organellen anreichern, werden letztere im Fluoreszenzmikroskop sichtbar. Unter violett-blauer Bestrahlung zeigen die einzelnen Plättchen mehrere sukzessive, blitzartige Zunahmen der Fluoreszenz-Intensität, wobei sie während einiger Sekunden vollständig ausgeleuchtet erscheinen. Die Blitze sind wahrscheinlich durch Freisetzung der fluoreszierenden Stoffe aus je einer 5HT-Speicherorganelle bedingt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. M. da Prada andA. Pletscher, Eur. J. Pharmac., in press.

  2. G. B. Picotti andI. Galatulas, Archo it. Pat. Chim. Tumori16, 101 (1973).

    Google Scholar 

  3. M. da Prada, K. von Berlepsch andA. Pletscher, Naunyn-Schmiedeberg's Arch. Pharmac.275, 315 (1972).

    Article  Google Scholar 

  4. M. da Prada andA. Pletscher, Br. J. Pharmac.34, 591 (1968).

    Article  Google Scholar 

  5. J. S. Ploem, Leitz-Mitt. Wiss. Tech.4, 225 (1969).

    Google Scholar 

  6. J. P. Tranzer, personal communication.

  7. H. Steffen, personal communication.

Download references

Author information

Authors and Affiliations

  1. Research Department, F. Hoffmann-La Roche & Co. Ltd, CH-4002, Basel, Switzerland

    H. P. Lorez, M. da Prada & A. Pletscher

Authors
  1. H. P. Lorez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. da Prada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Pletscher
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. We thank DrsH. R. Baumgartner andH. Steffen, Research Department, F. Hoffmann-La Roche & Co. Ltd, Basel, for advice in performing and interpreting the experiments.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lorez, H.P., da Prada, M. & Pletscher, A. Flashing phenomenon in blood platelets stained with fluorescent basic drugs. Experientia 31, 593–595 (1975). https://doi.org/10.1007/BF01932478

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01932478

Keywords

Search

Navigation