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Evidence against prostaglandin E having a physiological role in acetylcholine liberation from Auerbach's plexus of guinea-pig ileum

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Summary

The effect of INDO, a PGE synthesis inhibitor, on ACh output from Auerbach's plexus of guineapig ileum was investigated. INDO (15–45 μm/ml) failed to alter significantly either spontaneous ACh output or ACh output induced by field stimulation. It is concluded that PGE plays no physiological role in ACh liberation from this tissue.

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Authors and Affiliations

  1. Neurophysiology and Behavioral Research Branch, National Environmental Research Center, EPA, 27711, Research Triangle Park, North Carolina, USA

    J. Hazra

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  1. J. Hazra
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Additional information

I thankJ. Greenberg andJ. E. Comaty for their skillful assistance in the preparation of the longitudinal muscle strip and drug solutions. The research was done at New York State Res. Inst. for Neurochem. and Drug Addict., Ward's Isl., New York, and was supported in part with personal fund.

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Hazra, J. Evidence against prostaglandin E having a physiological role in acetylcholine liberation from Auerbach's plexus of guinea-pig ileum. Experientia 31, 565–566 (1975). https://doi.org/10.1007/BF01932460

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  • DOI: https://doi.org/10.1007/BF01932460

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