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Enhanced calcium accumulation related to increased protein phosphorylation in cardiac sarcoplasmic reticulum induced by cyclic 3′, 5′-AMP or isoproterenol

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Zusammenfassung

Die cAMP-abhängige Inkorporation von32P in das sarkoplasmatische Reticulum (SR) wurde im Zusammenhang mit Ca-Akkumulation in Kontrollherzen und in Herzen 2 h nach in vivo Verabreichung von 7,5 mg/kg Isoproterenol gemessen und gezeigt, dass die Katecholamine den intrazellulären Kalziumtransport in vitro sowie in vivo über die cAMP-stimulierte und PK-abhängige Phosphorylierung einer Proteinfraktion des SR regulieren.

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Authors and Affiliations

  1. Institute of Experimental Surgery, Department of Biochemistry, Slovak Academy of Sciences, Partizánska 2, 801 00, Bratislava, Czechoslovakia

    Margaret Fedelešová & A. Ziegelhöffer

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  1. Margaret Fedelešová
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  2. A. Ziegelhöffer
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Fedelešová, M., Ziegelhöffer, A. Enhanced calcium accumulation related to increased protein phosphorylation in cardiac sarcoplasmic reticulum induced by cyclic 3′, 5′-AMP or isoproterenol. Experientia 31, 518–520 (1975). https://doi.org/10.1007/BF01932432

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