, Volume 34, Issue 11, pp 1499–1501 | Cite as

Wound healing properties of naphthaquinone pigments fromAlkanna tinctoria

  • V. P. Papageorgiou


From the roots ofAlkanna tinctoria Tausch, the alkannin esters of the following acids were isolated and identified: β,β-dimethylacrylic acid, β-acetoxy-isovaleric acid, isovaleric acid, and angelic acid. These esteric pigments showed excellent wound healing properties in a clinical study on 72 patients with ulcus cruris.


Ester Clinical Study Wound Healing Healing Property Isovaleric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    R. Gunther, in: The Greek Herbal of Dioscorides, p. 421. (Hafner, New York 1959).Google Scholar
  2. 3.
    M. Grieve, in: A Modern Herbal, Hafner, New York 1959.Google Scholar
  3. 4.
    All the biological and clinical studies were performed using extract of the root ofAlkanna tinctoria, which I obtained from the Greek Pharmaceutical Company ‘Chropi SA’.Google Scholar
  4. 5.
    V.P. Papageorgiou, Chem. Chrom.7, 45 (1978).Google Scholar
  5. 6.
    V.P. Papageorgiou, Chem. Chron.6, 365 (1977).Google Scholar
  6. 7.
    R.H. Thomson, in: Naturally Occurring Quinones, p. 248. Academic Press, New York 1971; K. Bentley, in: The Natural Pigments, vol. 4, p. 204. Interscience, New York 1960.Google Scholar
  7. 8.
    V.P. Papageorgiou and G.A. Digenis, in preparation.Google Scholar
  8. 9.
    V.P. Papageorgiou, Planta Med.31, 390 (1977).Google Scholar
  9. 10.
    H. Brockmann, Annalen1, 521 (1936).Google Scholar
  10. 11.
    V.P. Papageorgiou, Deutsche Patentanmeldung, P 2700448.4 (1977).Google Scholar
  11. 12.
    B.N. Ames, J. McCann and E. Yamasaki, Mutation Res.31, 347 (1975).PubMedGoogle Scholar
  12. 13.
    V.P. Papageorgiou, A. Winkler, A. Sagredos and G. Digenis, Planta Med., in press (1978).Google Scholar
  13. 14.
    F. Heiss, Reichst., Aromen, Körperpflegem.4, 103 (1974).Google Scholar
  14. 15.
    The initial phase of the clinical studies was done at the dermatological ward of the Aristotle University of Thessaloniki (Greece). The studies were then continued at the dermatological ward of the Heidberg Hospital in Hamburg (Germany).Google Scholar
  15. 16.
    After 18 weeks this patient left the hospital and continued the treatment at home.Google Scholar
  16. 17.
    S.K. Gupta and I.S. Mathur, Indian. J. Cancer9, 50 (1972); Y.N. Shukla, J.S. Tandon, D.S. Bhakuni and M.M. Dhar, Phytochemistry,10, 1909 (1971).PubMedGoogle Scholar
  17. 18.
    S.C. Cohen, H.L. Gabelnick, R.K. Johnson and A. Goldin, Surgery78, 238 (1975).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • V. P. Papageorgiou
    • 1
  1. 1.Laboratory of Organic Chemistry, Department of Chemical Engineering, Polytechnical SchoolAristotle UniversityThessaloniki(Greece)

Personalised recommendations