Studies of the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configurations at C14′ and C16′ as well as the presence of the methoxycarbonyl group on C16′ seem to play an essential role in the determination of biological activity.
KeywordsBiological Activity Alkaloid Essential Role Vinblastine Methoxycarbonyl
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