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Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain

Experientia volume 34, pages 1488–1489 (1978)Cite this article

Summary

The effect of cerebroventricular injection of [D-Alanine] methionine-enkephalin (DALA), a synthetic analog of met-enkephalin, on the serotonergic system of rat brain has been studied. This opioid peptide caused an increase in 5HT turnover which was particularly evident in the limbic forebrain. This effect was completely antagonized by naloxone pretreatment.

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Author information

Author notes

  1. E. Puche Canas

    Present address: Departmento de Farmacologia y Terapeutica, Universidad de Granada, Spain

Affiliations

  1. Istituto di Richerche Farmacologiche ‘Mario Negri’, Via Eritrea, 62, I-20157, Milano, (Italy)

    A. Algeri, A. Consolazione, G. Calderini, G. Achilli, E. Puche Canas & S. Garattini

Authors
  1. A. Algeri
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  2. A. Consolazione
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  3. G. Calderini
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  4. G. Achilli
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  5. E. Puche Canas
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  6. S. Garattini
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Additional information

Acknowledgments. Support received from Tecnofarmaci, Rome, is gratefully acknowledged.

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Algeri, A., Consolazione, A., Calderini, G. et al. Effect of the administration of (d-Ala)2methionine-enkephalin on the serotonin metabolism in rat brain. Experientia 34, 1488–1489 (1978). https://doi.org/10.1007/BF01932370

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  • DOI: https://doi.org/10.1007/BF01932370

Keywords

  • Peptide
  • Serotonin
  • Naloxone
  • Synthetic Analog
  • Opioid Peptide