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Experientia

, Volume 34, Issue 11, pp 1436–1436 | Cite as

Studies on the hydrolysis of bradykinin by angiotensin-converting enzyme (kininase II)

  • F. E. Dorer
  • J. M. Stewart
  • J. W. Ryan
Article

Summary

Arg-Pro-Pro-Gly-Phe, the N-terminal pentapeptide of bradykinin, is not an inhibitor of angiotensin-converting enzyme and is not hydrolyzed by the enzyme. Arg-Pro-Pro, the N-terminal tripeptide is a relatively potent (IC50=2.3×106 M) inhibitor but its higher homolog, Gly-Arg-Met-Lys-Arg-Pro-Pro is not an inhibitor of angiotensin-converting enzyme.

Keywords

Enzyme Hydrolysis Bradykinin High Homolog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Literatur

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Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • F. E. Dorer
    • 1
    • 2
    • 3
  • J. M. Stewart
    • 1
    • 2
    • 3
  • J. W. Ryan
    • 1
    • 2
    • 3
  1. 1.Hypertension Research Laboratory, Veterans Administration Hospital andDepartment of BiochemistryCase Western Reserve UniversityClevelandUSA
  2. 2.Department of BiochemistryUniversity of Colorado Medical CenterDenverUSA
  3. 3.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

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