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Phosphatidyl-N-(2 hydroxyethyl)-alanine synthesis of distearoyl L-α-glycerylphosphoryl-N-(2 hydroxyethyl)-alanine

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Zusammenfassung

Die erste Synthese eines Phosphatidyl-N-(2 hydroxyethyl)-alanins wird beschrieben.

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Authors and Affiliations

  1. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

    S. K. Pavanaram & H. Flehmig

Authors
  1. S. K. Pavanaram
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  2. H. Flehmig
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Additional information

Dedicated to Professor Dr.Erich Baer in honour of his 70th birthday.

The nomenclature used in this communication is that used byFischer andBaer for well-nigh 4 decades. However, according to the rules of IUPAC-IUB commission this should be 1,2-distearoylsn-glycero-3-phosphoryl-N-(2-hydroxyethyl)-alanine.

The authors thank the National Institute of Health (USA) and the Medical Research Council (Canada) for making the grants available to ProfessorE. Baer, which made this work possible.

The authors thank Dr.J. von Euw and Professor Dr.T. Reichstein of the University of Basel (Switzerland) for kindly providing the rotation. As the optical purity is a very important criterion of the activity of the phospholipids; this has been determined on the Schmid and Heansch polarimeter (visual) as well as on the Perkin Elmer polarimeter (photoelectric) with excellent agreement.

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Pavanaram, S.K., Flehmig, H. Phosphatidyl-N-(2 hydroxyethyl)-alanine synthesis of distearoyl L-α-glycerylphosphoryl-N-(2 hydroxyethyl)-alanine. Experientia 28, 498–499 (1972). https://doi.org/10.1007/BF01931838

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  • DOI: https://doi.org/10.1007/BF01931838

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