, Volume 48, Issue 3, pp 262–265 | Cite as

Hormonal control of manganese transport in the mouse thyroid

  • M. Nishida
  • J. Kawada


The present study deals with a possible mechanism controlling the transport of manganese (Mn), an essential trace element, from the circulation to the thyroid. Mice were pretreated with propylthiouracil (PTU) or triiodothyronine (T3), and a measurement of the thyroid:serum concentration ratio (T/S) of radioactive manganese (54Mn) was carried out. The T/S of54Mn was greatly enhanced by PTU, but reduced by T3. Several methods were used to demonstrate that the T/S of54Mn depends upon the level of thyroid-stimulating hormone (TSH) in the serum. First, bovine TSH was injected into mice; an increase in the T/S resulted. Secondly, serum thyroxine and T3 levels measured by radioimmunoassay (RIA) suggested that PTU produced an increase in serum TSH and T3 a decrease. However, direct measurement of mouse TSH by RIA for rat TSH failed to produce proof of any changes in TSH level, owing to poor cross-reactivity. Taking all the information into account, it is concluded that Mn-transport into the thyroid is controlled by the thyroid state.

Key words

Manganese thyroid thyroxine triiodothyronine metal transport 


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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • M. Nishida
    • 1
  • J. Kawada
    • 1
  1. 1.Faculty of Pharmaceutical SciencesThe University of TokushimaTokushima(Japan)

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