, Volume 49, Issue 12, pp 1095–1097 | Cite as

Anti-lipopolysaccharide activity of histatins, peptides from human saliva

  • K. Sugiyama
Research Articles


Histatins are histidine-rich polypeptides secreted in human saliva. They were found to inhibit lipopolysaccharide (LPS)-mediated gelation of Limulus amoebocyte lysate, and to reverse the anti-complement action of LPS or lipid A. Histatins also gave precipitate bands in agarose gels with various LPS. The results indicate that histatins neutralized the activity of LPS by binding to the lipid A moiety of LPS.

Key words

Histatins human saliva LPS Limulus test hemolysis 


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  1. 1.
    Sugiyama, K., Suzuki, Y., and Furuta, H. Life Sci.37 (1985) 475.CrossRefPubMedGoogle Scholar
  2. 2.
    Oppenheim, F. G., Xu, T., McMillian, F. M., Levitz, S. M., Diamond, R. D., Offiner, G. D., and Troxler, R. F., J. biol. Chem.263 (1988) 7472.PubMedGoogle Scholar
  3. 3.
    Troxler, R. F., Offiner, G. D., Xu, T., Vanderspek, J. C., and Oppenheim, F. G., J. dent. Res.69 (1990) 2.PubMedGoogle Scholar
  4. 4.
    MacKay, B. J., Denepitiya, L., Iacono, V. J., Krost, S. B., and Pollock, J. J., Insect. Immun.44 (1984) 695.Google Scholar
  5. 5.
    Pollock, J. J., Denepitiya, L., MacKay, B. L., and Iacono, V. J., Infect. Immun.44 (1984) 44.Google Scholar
  6. 6.
    Hay, D. I., Archs oral Biol.18 (1973) 1517.CrossRefGoogle Scholar
  7. 7.
    Sugiyama, K., Ogino, T., and Ogata, K., Archs oral Biol.35 (1990) 415.CrossRefGoogle Scholar
  8. 8.
    Morrison, D. C., and Kline, L. F., J. Immun.118 (1977) 362.PubMedGoogle Scholar
  9. 9.
    Kitamura, H., Inai, S., and Nagaki, K., Jap. J. clin. Chem.12 (1983) 143.Google Scholar
  10. 10.
    Westphal, O., Int. Archs Allergy appl. Immun.49 (1975) 1.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1993

Authors and Affiliations

  • K. Sugiyama
    • 1
  1. 1.Department of PharmacologyOkayama University Dental SchoolOkayama(Japan)

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