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Experientia

, Volume 49, Issue 12, pp 1092–1094 | Cite as

Lactate dehydrogenase and glutamate dehydrogenase activities in the circumventricular organs of rat brain following neonatal monosodium glutamate

  • M. Bawari
  • G. N. Babu
  • M. M. Ali
  • U. K. Misra
  • S. V. Chandra
Research Articles

Abstract

Glutamate (glu) an excitatory neurotransmitter amino acid, is present in high concentrations in the mammalian central nervous system and is the most abundant amino acid in our daily diet. In the present study the activities of lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH) were evaluated in the circumventricular organs (CVO) of the brain in 25-day-old rats following MSG administration at a dose of 4 mg/g b.wt during the first ten days of life. The results show the LDH activity increased to 265% of that in the control (p<0.001), whereas GDH activity was significantly decreased (p<0.05), The great elevation in LDH, a cytoplasmic marker enzyme, is apparently due to cytoskeletal changes brought about as a consequence of glu toxicity, whereas lowered GDH activity indicates altered glu homostasis in the blood-brain-barrier deficient areas following neonatal exposure to glu.

Key words

Monosodium glutamate LDH GDH excitotoxin blood-brain barrier 

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Copyright information

© Birkhäuser Verlag Basel 1993

Authors and Affiliations

  • M. Bawari
    • 1
  • G. N. Babu
    • 1
  • M. M. Ali
    • 2
  • U. K. Misra
    • 1
  • S. V. Chandra
    • 2
  1. 1.Department of NeurologySGPG Institute of Medical SciencesLucknow(India)
  2. 2.Division of NeurotoxicologyIndustrial Toxicology Research CentreLucknow(India)

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