Experientia

, Volume 47, Issue 9, pp 964–968 | Cite as

Some extracellular matrix elements as markers of ‘capillary tunnels’ in hypertrophied rat heart

  • A. Ratajska
  • Z. Gawlik
  • E. Fiejka
Research Articles

Abstract

We studied the distribution of the extracellular matrix proteins fibronectin (FN) and laminin (LM) in the hypertrophied hearts of spontaneously hypertensive rats (SHR), using an immunofluorescence method with specific antibodies. The immunohistochemical reaction was positive in the cytoplasm of some hypertrophied cardiomyocytes. The results showed that FN and LM can be used as markers for tunnels, i.e. intracardiocytic invaginations of the sarcolemma. The tunnels observed contained capillaries.

Key words

Heart hypertrophy spontaneously hypertensive rats tunnel capillaries fibronectin laminin immunohistochemical staining 

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References

  1. 1.
    Ruoslahti, R., A. Rev. Biochem.57 (1988) 375.Google Scholar
  2. 2.
    Hynes, R. O., and Yamada, K. M., J. Cell. Biol.95 (1982) 369.PubMedGoogle Scholar
  3. 3.
    Timpl, R., Rohde, H., Gehron-Robey, P., Rennard, S. I., Foidart, J. M., and Martin, G. R., J. Biol. Chem.254 (1979) 9933.PubMedGoogle Scholar
  4. 4.
    Liotta, L. A., Cancer Res.46 (1986) 1.PubMedGoogle Scholar
  5. 5.
    Saxen, L., Ekbolm, P., and Thesleff, I., New Trends in Basement Membrane Research, p. 257. Eds K. Kuehn, H. Schoene and R. Timpl. Raven Press, New York 1982.Google Scholar
  6. 6.
    Grant, D. S., Tashiro, K. I., Segui-Real, B., Yamada, Y., Martin, G. R., and Kleinman, H. K. Cell58 (1989) 933.PubMedGoogle Scholar
  7. 7.
    Ingber, D. E., Proc. natl Acad. Sci. USA87 (1990) 3579.PubMedGoogle Scholar
  8. 8.
    Cutiletta, A. F., Benjamin, M., Culpepper, W. S., and Oparil, S., J. molec. Cell Cardiol.10 (1978) 689.Google Scholar
  9. 9.
    Platt, J. L., and Michael, A. F., J. Histochem. Cytochem.31 (1983) 840.PubMedGoogle Scholar
  10. 10.
    Linzbach, A. J., Am. J. Cardiol.5 (1960) 370.PubMedGoogle Scholar
  11. 11.
    Kawamura, K., Kashii, C., and Imamura, K., Jap. Circ. J.40 (1976) 1119.PubMedGoogle Scholar
  12. 12.
    Imamura, K., Jap. Circ. J.42 (1978) 979.PubMedGoogle Scholar
  13. 13.
    Bishop, S. P., Dillon, D., Naftilan, J., and Reynolds, R., Scanning Electron Microsc.2 (1980) 193.Google Scholar
  14. 14.
    Tomanek, R. J., Searls, J. C., and Lachenbrach, P. A., Circ. Res.51 (1982) 295.PubMedGoogle Scholar
  15. 15.
    Wohlfart, G., J. Neuropath. exp. Neurol.10 (1951) 109.PubMedGoogle Scholar
  16. 16.
    Reitsma, W., Angiology24 (1973) 45.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • A. Ratajska
    • 1
  • Z. Gawlik
    • 1
  • E. Fiejka
    • 1
  1. 1.Department of Pathological Anatomy, Institute of BiostructureMedical Academy of WarsawWarsawPoland

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