, Volume 47, Issue 9, pp 964–968 | Cite as

Some extracellular matrix elements as markers of ‘capillary tunnels’ in hypertrophied rat heart

  • A. Ratajska
  • Z. Gawlik
  • E. Fiejka
Research Articles


We studied the distribution of the extracellular matrix proteins fibronectin (FN) and laminin (LM) in the hypertrophied hearts of spontaneously hypertensive rats (SHR), using an immunofluorescence method with specific antibodies. The immunohistochemical reaction was positive in the cytoplasm of some hypertrophied cardiomyocytes. The results showed that FN and LM can be used as markers for tunnels, i.e. intracardiocytic invaginations of the sarcolemma. The tunnels observed contained capillaries.

Key words

Heart hypertrophy spontaneously hypertensive rats tunnel capillaries fibronectin laminin immunohistochemical staining 


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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • A. Ratajska
    • 1
  • Z. Gawlik
    • 1
  • E. Fiejka
    • 1
  1. 1.Department of Pathological Anatomy, Institute of BiostructureMedical Academy of WarsawWarsawPoland

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