Abstract
The effects of a potent phosphatase inhibitor, calyculin A (CL-A), on inward currents in guinea pig taenia coli smooth muscle cells were examined. CL-A increased the inward current, and this effect of CL-A was inhibited by a protein kinase C inhibitor, H-7, and by nifedipine. Phorbol 12,13-dibutyrate, an activator of protein kinase C, also increased the inward current and this effect was antagonized by H-7. These results suggest that in guinea pig taenia coli smooth muscle cells CL-A may facilitate the opening of thel-type Ca2+ channels through the protein kinase C-dependent phosphorylation system.
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Usuki, T., Obara, K., Someya, T. et al. Calyculin a increases voltage-dependent inward current in, smooth muscle cells isolated from guinea pig taenia coli. Experientia 47, 939–941 (1991). https://doi.org/10.1007/BF01929886
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DOI: https://doi.org/10.1007/BF01929886