, Volume 51, Issue 2, pp 141–149 | Cite as

Components of biological, including seasonal, variation in hematological measurements and plasma fibrinogen concentrations in normal humans

  • M. Maes
  • S. Scharpé
  • W. Cooreman
  • A. Wauters
  • H. Neels
  • R. Verkerd
  • F. De Meyer
  • P. D'Hondt
  • D. Peeters
  • P. Cosyns


This study has been carried out in order to examine the components of biologicalaand, in particular, seasonal variation in hematologic measurements in normal humans. Toward this end, 26 normal volunteers had monthly blood samplings during one calendar year for determination of number of red blood cells (RBC) and platelets, hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV), MC Hb (MCH), MC Hb concentration (MCHC), RBC distribution width (RDW), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and plasma fibrinogen concentrations. The data were analyzed by means of spectral analyses of a group of time series or a single time series, and by means of repeated measures analyses of variance. Most of the hematologic variables show seasonal rhythms, such as annual rhythms or harmonics, which are expressed as a group phenomenon. An important part of the variance (>15%) in Ht, MCV, MCH, MCHC, RDW, number of platelets, MPV and plasma fibrinogen was explained by a yearly variation. The peak-trough differences (expressed as a percentage of the mean) in the yearly variations in number of RBC, Ht, MCV, MCH, MCHC and RDW were very low (all<8.5%). Number of platelets (14.4%) and plasma fibrinogen values (28%) showed a high-amplitude yearly variation. All hematological variables, except MCHC, show a high interindividual variability which exceeds by far the intraindividual variability.

Key words

Seasonality annual rhythms hematology red blood cells platelets fibrinogen biological variation coefficient of variation index of individuality 


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Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • M. Maes
    • 1
  • S. Scharpé
    • 2
  • W. Cooreman
    • 3
  • A. Wauters
    • 4
  • H. Neels
    • 4
  • R. Verkerd
    • 5
  • F. De Meyer
    • 5
  • P. D'Hondt
    • 6
  • D. Peeters
    • 6
  • P. Cosyns
    • 6
  1. 1.AZ StuivenbergUniversity Department of PsychiatryAntwerp(Belgium)
  2. 2.Department of Medical BiochemistryUniversity of AntwerpAntwerp
  3. 3.Laboratory of Clinical BiologySt-Augustinus ZiekenhuisAntwerp
  4. 4.Laboratory of Clinical BiologyMiddelheim ZiekenhuisAntwerp
  5. 5.Royal Meterological InstituteBrussels
  6. 6.University Hospital of Antwerp(Belgium)

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