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Paradoxical inhibition of the effects of bradykinin by some sulfhydryl reagents

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Résumé

Plusieurs dérivés thiol et deux antioxidants inhibent la bronchoconstriction chez le cobaye, une partie de l'hypotension chez le lapin et la libération de «rabbit aorta contracting substance» (RCS) dues à la bradykinine Il est proposé que les effets communs à la bradykinine, à la SRS-A, SRS-C et à l'acide arachidonique, qui sont bloqués par des antiinflammatoires, acides, et par les dérivés thiol, sont dus à la formation de RCS, constituée par des péroxydes cicliques analogues aux précurseurs instables des prostaglandines E 2 et F 2 alpha.

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Authors and Affiliations

  1. Organon S. A., F-60, Eragny-sur-Epte, France

    B. B. Vargaftig & Nguyen Dao Hai

Authors
  1. B. B. Vargaftig
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  2. Nguyen Dao Hai
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Additional information

We thank MrsB. Charpentier andC. Bellevrat for technical help, Prof.H. Clauser andJ. R. Vane and DrH. O. J. Collier for comments and DrS. H. Ferreira for advice concerning the superfusion technique and for BPP9. Squibb provided BPP5. This work is part of a thesis leading to the degree of Docteur-ès-Sciences, Orsay (B.B.V.).

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Vargaftig, B.B., Hai, N.D. Paradoxical inhibition of the effects of bradykinin by some sulfhydryl reagents. Experientia 28, 59–62 (1972). https://doi.org/10.1007/BF01928265

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