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Two new short-acting non-depolarizing neuromuscular blocking agents

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Résumé

Le chlorure de 1,1′-octaméthylène et le méthylsulfate de 5,5′-octaméthylènebis ont chez le chat un effet de blocage neuro-musculaire non dépolarisant, de courte durée. Les comparaisons faites avec des analogues voisins suggèrent que l'activité de ces composés est influencée par le degré d'empêchement stérique autour des atomes d'azote quaternaire. Les composés inhibent les acétylcholinestérases et s'opposent à des degrés divers aux effects muscariniques de l'acétylcholine.

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Authors and Affiliations

  1. The Wellcome Research Laboratories, BR3 3BS, Beckenham, Kent, England

    F. C. Copp, G. G. Coker, A. F. Green, R. Hughes & R. H. Nimmo-Smith

Authors
  1. F. C. Copp
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  2. G. G. Coker
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  3. A. F. Green
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  4. R. Hughes
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  5. R. H. Nimmo-Smith
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Copp, F.C., Coker, G.G., Green, A.F. et al. Two new short-acting non-depolarizing neuromuscular blocking agents. Experientia 28, 47–48 (1972). https://doi.org/10.1007/BF01928257

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  • DOI: https://doi.org/10.1007/BF01928257

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